3-MeO-PCP (3-Methoxyphencyclidine) | Analytical Reference Standard

Are you seeking a verified, high-purity source for buy 3-MeO-PCP online in Europe? 3-MeO-PCP (3-methoxyphencyclidine) is a potent dissociative of the arylcyclohexylamine class and a prominent derivative of PCP. Within the scientific community, it is a primary subject for researchers investigating the Structure-Activity Relationship (SAR) of aminergic GPCRs and the specific influence of the 3-methoxy group on the potency and receptor selectivity of the phencyclidine backbone.

We provide analytical-grade 3-MeO-PCP hydrochloride, verified via HPLC and LC-MS to ensure the $\geq$ 98% purity required for rigorous in vitro pharmacological investigations and structural biology studies.

Pharmacological Profile & Mechanism of Action

3-MeO-PCP is utilized as a sophisticated chemical probe to study the biochemical markers of central nervous system (CNS) modulation. Researchers utilize this compound to explore:

NMDA Receptor Antagonism: Acting as a high-affinity non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor. It binds to the PCP site within the ion channel, modulating excitatory neurotransmission.
Monoamine Reuptake Inhibition: Distinguished by its significant affinity as a serotonin reuptake inhibitor (SRI), as well as acting on dopamine and norepinephrine transporters. This distinguishes its neurochemical profile from unsubstituted PCP.
Sigma-1 Receptor Affinity: Researching its activity as a high-affinity ligand for the $\sigma_{1}$ receptor, contributing to its complex profile as a tool for studying neuronal survival and signaling.

Primary Research & Forensic Applications

Buy 3-MeO-PCP online in Europe is an essential reference material for several advanced scientific domains:

Neuroscience Research: Exploring the modulation of neuronal signaling and the impact of 3-position methoxylation on the potency of arylcyclohexylamines.
Forensic Toxicology: Serving as a validated reference standard (CAS: 72242-03-6) for LC-MS/MS and GC-MS libraries to identify and quantify novel psychoactive substances (NPS).
Structure-Activity Relationship (SAR) Mapping: Utilizing 3-MeO-PCP as a probe to understand how small structural changes alter the selectivity between NMDA and monoaminergic targets.
Metabolic Mapping: Investigating the metabolic pathways of methoxylated PCP analogs, focusing on O-demethylation and hydroxylation in in-vitro hepatic models.

Technical Specifications

Feature	Details
IUPAC Name	1-[1-(3-methoxyphenyl)cyclohexyl]piperidine
CAS Number	72242-03-6
Molar Mass	273.41 g/mol (Base)
Purity Grade	Analytical Research Grade ( $\geq$ 98%)
Molecular Formula	$C_{18}H_{27}NO \cdot HCl$

Safety, Regulatory Status, and Procurement

3-MeO-PCP is intended strictly for laboratory research and is NOT for human or veterinary consumption.

Regulatory Compliance: Researchers must ensure procurement aligns with local jurisdictional laws regarding PCP analogs. In many regions, 3-MeO-PCP is controlled under “analogue” or “designer drug” legislation.
Handling & PPE: Due to extreme physiological activity at low milligram levels, the use of Personal Protective Equipment (PPE), including nitrile gloves, eye protection, and a fume hood, is mandatory.
Storage: To maintain maximum molecular stability and prevent degradation, store in a cool, dry, and dark environment in airtight containers.

Why Source Through Licensed Distribution Channels?

Verified Analytical Integrity: Every batch is independently tested to ensure your research is conducted with materials of known concentration and high purity.
Chain of Custody: Professional logistics ensure tracked, secure shipping, maintaining the compliance required for institutional and academic facilities.
Technical Documentation: Orders are supported by batch-specific Certificates of Analysis (COA) and Safety Data Sheets (SDS) for institutional safety audits.

Buy 3-MeO-PCP online in Europe | Research Chemicals Netherlands

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